Republic Act 6969 (R.A. 6969), known as the “Toxic Substances and Hazardous and Nuclear Waste Control Act of 1990”, is the key legislation on the management of chemical substances and mixtures in the Philippines published by the Department of Environment and Natural Resources (DENR) in 1990. It is stipulated that new chemical substances should obtain a corresponding compliance certificate before the first manufacture/importation. This seminar will mainly focus on the scope of notification, notification type, the requirements of different kinds of notifications and practical guidance of the OPMS system.