The intermediate, which plays a key role in the global chemical industry, is treated and regulated variously by countries and regions. Although the risks of intermediate are manageable compared with other chemicals, it is necessary to control and monitor the risk of exposure to human health and the environment. MEE Order No.12 significantly decreases the data requirements for intermediates, thereby releasing the burden of companies. However, in practice, there are still some difficulties in intermediates registration. With the implementation of MEE Order No.12 for over 1 year, REACH24H schedules a webinar with a special focus on intermediates registration under this measure.