India Chemicals (Management and Safety) Rules, ICMSR, a draft was firstly released on Nov. 2019 and has been revised multiple times. The latest and the fifth version was published on Aug.24th,2020. ICMSR was planned to be in force in early 2021. It will give comprehensive management on the new/existing substances, priority substances, hazardous substances. This presentation will include a brief understanding of the framework of ICMSR and how to comply with the notification and registration, which will give a big effect on global companies.