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China MEE Soliciting Computational Toxicological and Exposure Prediction Software/Model

On March 4, 2021, the Solid Waste and Chemicals Management Center (SCC) under the Chinese Ministry of Ecology and Environment (MEE) published a notice [1] to solicit computational toxicological and exposure prediction software/models for chemical substances.

According to the notice, the SCC plans to establish a library for feasible software and models. Notably, the adopted software will be used in the screening for environmental risk assessment of chemical substances, and those which can predict the reproductive toxicity and repeated dose toxicity of chemicals will be recommended for environmental management registration of new chemicals.

The models or software submitted should be able to predict relevant data of chemical substances, including physical and chemical properties data (melting point, boiling point, partition coefficient, etc.), toxicological data (acute toxicity, carcinogenicity, mutagenicity, etc.), ecotoxicological data (acute/chronic aquatic toxicity, etc.), environmental behavioral data, environmental exposure data, and so on.

The notice provides that applicants shall submit their models along with the processes documentation for model development, such as prediction endpoints, application domain, clear and transparent algorithms, etc. in the case of computational toxicological models, and exposure scenarios, release sources, release scenarios, etc. in the case of exposure prediction models. In terms of software, applicants shall submit stand-alone software and their user manuals.

According to an official with the SCC, the models and software, once adopted, will be used in the registration of new chemical substances, hazard screening of new pollutants, screening of priority control substances, preparation of lists of toxic and hazardous air and water pollutants, risk assessment of chemicals, etc., thus playing an important role in the decision-making work of the MEE.

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