On April 1, 2020, the Japanese Ministry of Economy, Trade and Industry (METI) announced that six substances [1] will be added to the list of Priority Assessment Chemical Substances (PACs) under the country’s Chemical Substance Control Law (CSCL) [2]. Another notice issued on the previous day made public the removal of three substances [3] from it.
The details of changes to the list are presented in the table below.
Substance name | |
Substances added into list
| Hydrogen cyanide |
Diethyl phthalate (DEP) | |
5-chloro-2-(4-chlorophenoxy)phenol | |
4,4-diamino-3,3-dichlorodiphenylmethane [synonym: 4,4'-methanediylbis(2-chloroaniline)] | |
Mixture of bicyclo[2.2.1]heptane-2,5(or 2,6)-diyldicyanide | |
Salts of poly[iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl] hydrochloride, limited to those formed with addition of a proton to the nitrogen atom | |
Substances removed from the list | Pyridine-triphenylborane(1/1) |
N,N-Dimethylpropane-1,3-diyldiamine | |
Manganese N,N'-ethylenebis(dithiocarbamate) (synonym: Maneb) |
Under the framework of CSCL, certain substances will be selected from general chemical substances and new chemical notifications for risk screening and assessment. Those with potential risks of long-term toxicity for humans or the environment will be designated as PACs. To effectively regulate substances on the list, PACs manufactured/imported in an amount of 1 ton/year or more are subject to specific annual notification requirements.


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