On October 29, 2021, Japan's Ministry of Health, Labour and Welfare (MHLW), Ministry of Economy, Trade and Industry (METI), and Ministry of Environment (MoE) jointly published the 2022 schedule for small-quantity notification of new chemicals. As stipulated in Clause V, Article 3 (1) of Japan Chemical Substance Control Law (CSCL), businesses to manufacture or import new chemical substances with environmental release volume of less than 1 ton/year across the nation are obliged to apply for small-quantity notification prior to manufacture or import.